The main cast is expected to include Kafka Hibino (the protagonist who can transform into Kaiju No. 8), Mina Ashiro (a top Defense Force officer and Kafka's childhood friend), and supporting characters like Reno Ichikawa and Kikoru Shinomiya.

Season 2 Episode 3 may introduce new kaiju antagonists or deepen existing character arcs, particularly exploring Kafka's internal conflict between his human identity and kaiju powers.